Acetylcholine receptors (AChRs)

Acetylcholine receptors (AChRs) are integral membrane proteins that respond to the binding of acetylcholine, a neurotransmitter. They play crucial roles in neurotransmission throughout the nervous system. They are classified into two major types: nicotinic acetylcholine receptors (nAChRs), which are ionotropic receptors functioning as ligand-gated ion channels, and muscarinic acetylcholine receptors (mAChRs), which are metabotropic receptors belonging to the G protein-coupled receptor (GPCR) superfamily. AChRs mediate the effects of acetylcholine throughout the nervous system and in non-nervous tissues and are considered important therapeutic targets in various neurological and neuromuscular conditions.

Other names

AChRs