Target intelligence / Profile preview

Acetylcholinesterase (AChE) (AChE)

Target: AChE
Molecular classification: Enzyme, Hydrolase, Carboxylesterase family member

Overview

Other names: Acetylcholine acetylhydrolaseAChaseacetylhydrolaseCholinesterase (when referring to AChE specifically)ACHE (gene symbol)

Biological functions

Termination of cholinergic synaptic transmissionHydrolysis of acetylcholine into choline and acetateRegulation of neuromuscular junction activityModulation of neurotransmission and synaptic plasticityInvolvement in non-cholinergic signaling pathways (e.g., JNK pathway activation, interaction with microRNAs)

Disease associations

Neurodegenerative disease (e.g., Alzheimer’s disease)Myasthenia gravis and other neuromuscular disordersOrganophosphate poisoningPost-stroke aphasia and cognitive impairment

Interacting drugs

Donepezil

2 more in the full profile.

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