Gosset Molecular Classification
Enzyme, Hydrolase
Other Names
Acid phosphomonoesterase, Phosphomonoesterase, Glycerophosphatase, Acid monophosphatase, Acid phosphohydrolase
Disease Roles
Acid Phosphatase Overview
Acid phosphatase is a hydrolase enzyme that catalyzes the hydrolysis of phosphate esters, releasing inorganic phosphate and an alcohol in acidic conditions. It is found across a wide range of organisms and has multiple isoforms with distinct tissue distributions. It plays roles in cellular catabolism, bone resorption, and phosphate mobilization. Elevated levels can serve as diagnostic markers for various diseases, including prostate cancer and bone disorders.
Mechanism of Action
Hydrolyzes phosphate monoesters to release inorganic phosphate.
Biological Functions
Hydrolysis of phosphate esters
Mobilization of organic phosphorus
Cellular catabolism
Bone resorption
Disease Associations
Prostate cancer
Bone disorders
Osteoporosis
Paget's disease
Safety Considerations
No safety concerns listed
Associated Biomarkers
| Biomarker |
|---|
| Prostatic acid phosphatase (PAP) for prostate cancer (historical) |
| Tartrate-resistant acid phosphatase (TRAP) for bone resorption |