Target intelligence / Profile preview

Acid Phosphatase

Molecular classification
Enzyme, Hydrolase
01

Overview

Acid phosphatase is a hydrolase enzyme that catalyzes the hydrolysis of phosphate esters, releasing inorganic phosphate and an alcohol in acidic conditions. It is found across a wide range of organisms and has multiple isoforms with distinct tissue distributions. It plays roles in cellular catabolism, bone resorption, and phosphate mobilization. Elevated levels can serve as diagnostic markers for various diseases, including prostate cancer and bone disorders.

Other names
Acid phosphomonoesterasePhosphomonoesteraseGlycerophosphataseAcid monophosphataseAcid phosphohydrolase
02

Mechanism of action

Hydrolyzes phosphate monoesters to release inorganic phosphate.

03

Biological functions

Hydrolysis of phosphate estersMobilization of organic phosphorusCellular catabolismBone resorption
04

Disease associations

Prostate cancerBone disordersOsteoporosisPaget's disease
05

Biomarkers

Prostatic acid phosphatase (PAP) for prostate cancer (historical)Tartrate-resistant acid phosphatase (TRAP) for bone resorption

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