Acid phosphatase 2, lysosomal (ACP2)

Acid phosphatase 2, lysosomal (ACP2) is an enzyme localized to the lysosomal membrane, belonging to the histidine acid phosphatase family. It catalyzes the hydrolysis of phosphate monoesters, vital for lysosomal function and cellular homeostasis[1][3][4]. Chemically and genetically distinct from red cell acid phosphatase, ACP2 consists of alpha and beta subunits, with the beta subunit encoded by the *ACP2* gene[4]. Deficiency or mutations in ACP2 cause lysosomal storage disorders, altered neurodevelopment, bone and skin defects, and increased seizure susceptibility[1][3]. Increased ACP2 expression has been observed in several human malignancies, notably in colorectal cancer, where it serves as both an unfavorable prognostic factor and a chemosensitivity biomarker for 5-FU-based therapies[2]. ACP2 is also implicated as a disease risk factor in neurodegenerative disorders such as progressive supranuclear palsy and Batten disease[1][3].

Other names

Lysosomal acid phosphataseLAPacid phosphatase 2, lysosomal

For 5-FU: Chemotherapeutic mechanism; ACP2 increases chemosensitivity, loss of ACP2 leads to chemoresistance