Acoustic Impedance Mismatch (Microbubble Reflection) (AIM)

Ultrasound imaging enhancement via acoustic impedance mismatch leverages the physical principle that when an ultrasound wave encounters a boundary between two materials with different acoustic impedances, part of the wave is reflected back. Microbubbles, which have a gas core encapsulated by a shell, create a strong acoustic impedance mismatch with surrounding biological tissues or fluids. This results in pronounced reflection and scattering of ultrasound waves at the microbubble interface, significantly enhancing image contrast and signal-to-noise ratio. The 'target' is the interface between the microbubble gas core and the surrounding liquid or tissue, where the difference in acoustic impedance is maximized for optimal reflectivity.

Other names

Microbubble Contrast EnhancementUltrasound Contrast ImagingAcoustic Reflection Enhancement

N/A - Not a drug target