Acquired salivary pellicle (ASP) (ASP)

The acquired salivary pellicle (ASP) is a thin, acellular, organic film that forms on the tooth surface immediately after exposure to saliva. It is composed of a complex mixture of salivary proteins, glycoproteins, lipids, and enzymes that selectively adsorb onto the hydroxyapatite of the enamel (Siqueira et al., 2012, J Dent Res). The ASP serves several critical biological functions, including lubricating the oral surfaces to prevent wear, regulating mineral exchange between the tooth and saliva, and acting as a semi-permeable barrier against dietary acids (Hannig & Hannig, 2009, Monogr Oral Sci). However, it also serves as the primary substrate for the initial attachment of oral bacteria, leading to the formation of dental plaque and subsequent diseases such as caries and periodontitis (Lendenmann et al., 2000, Crit Rev Oral Biol Med). Therapeutic strategies targeting the ASP often focus on modifying its composition to enhance its protective properties or to inhibit the adhesion of pathogenic microorganisms (Vacca-Smith & Bowen, 2000, Arch Oral Biol). Drugs such as chlorhexidine and fluoride interact with the pellicle to provide antimicrobial effects or strengthen the enamel-pellicle interface.

Other names

Dental pellicleSalivary pellicleEnamel pellicleAcquired enamel pellicle (AEP)

Modification of pellicle composition to inhibit bacterial adhesion, enhancement of remineralization, and provision of a physical barrier against acid-induced demineralization.