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Target intelligence / Profile preview
Actin epsilon 1, pseudogene (ACTE1P)
- Target
- ACTE1P
- Molecular classification
- Pseudogene, Long non-coding RNA (lncRNA)
01
Overview
Actin epsilon 1, pseudogene (ACTE1P) is a non-coding RNA located at cytogenetic region 11q13.4 (chr11:71,382,456-71,423,730, hg38), designated as a processed pseudogene and lncRNA. It has no protein-coding function and is not an active molecular entity. ACTE1P is adjacent to the DHCR7 gene, and genetic variant rs12803256 in ACTE1P has been strongly associated with serum vitamin D levels, possibly due to a regulatory effect on DHCR7 expression. Its biological or pathological function remains unclear, and no drugs target ACTE1P directly. The classification of ACTE1P as a therapeutic target is incorrect, as pseudogenes generally lack canonical target functions[7][1][3][5].
02
Mechanism of action
None (no mechanism, as no drugs interact)
03
Biological functions
Putative regulatory element (may act as enhancer or promoter for nearby genes, e.g., DHCR7)Other (not experimentally validated biological function; sequence is non-coding)
04
Disease associations
Other (single nucleotide polymorphism rs12803256 in ACTE1P has been associated via GWAS with serum vitamin D levels, likely through a regulatory effect on the nearby DHCR7 gene, but not directly implicated in common diseases like cancer, inflammation, etc.)
05
Biomarkers
rs12803256 SNP (may be considered a biomarker for variation in serum vitamin D levels)
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