Actin gamma 2, smooth muscle (ACTG2)

Actin gamma 2, smooth muscle (ACTG2) is a member of the actin family of highly conserved cytoskeletal proteins. Specifically, ACTG2 encodes the smooth muscle–specific γ2 actin isoform that is critical for the formation and function of contractile filaments in enteric and visceral smooth muscle cells, such as those of the gastrointestinal and urinary tracts[1][2][3][4][6]. This protein is essential for the contraction required to move food through the intestines and expel urine from the bladder[1][2][3]. Mutations in ACTG2 disrupt filament polymerization, resulting in impaired muscle contractility and visceral myopathies like MMIHS and familial visceral myopathy, which present as severe GI and urinary dysmotility[1][3][5][7]. ACTG2 is not a drug target, but its variant status can serve as a diagnostic biomarker for visceral myopathies[5].

Other names

ACTACTA3ACTEACTL3ACTSGVSCMactingamma-enteric smooth muscle isoform 1 precursorgamma-enteric smooth muscle isoform 2 precursoractin-like proteinalpha-actin-3

Not applicable; no drugs directly target ACTG2