Activated Microglia ()

Activated Microglia Overview

Activated microglia are the resident immune cells of the central nervous system (CNS) that respond to injury, infection, or disease by shifting from a surveillant state to an activated state. In their activated form, microglia play a central role in neuroinflammation and are key mediators of both protective and pathological processes within the CNS. They can polarize into different functional phenotypes, primarily M1 (pro-inflammatory) and M2 (anti-inflammatory/tissue repair), though recent research suggests a spectrum of activation states. Targeting activated microglia is being explored as a therapeutic strategy for various neurological diseases.

Mechanism of Action

Modulation of microglial activation state (e.g., shifting from M1 to M2 phenotype, inhibiting pro-inflammatory cytokine release)

Biological Functions

Safety Considerations

Associated Biomarkers