Activating transcription factor 5 mRNA 3' untranslated region (ATF5 mRNA 3'UTR) (ATF5 mRNA 3'UTR)

The Activating transcription factor 5 (ATF5) mRNA 3' untranslated region (3'UTR) is a critical regulatory segment of the ATF5 transcript that controls the stability and translation of the ATF5 protein (Greene et al., 2009, PMID: 19430486). ATF5 is a member of the basic leucine zipper (bZIP) family of transcription factors and plays a pivotal role in promoting cell survival and inhibiting apoptosis, particularly under stress conditions (Sheng et al., 2010, PMID: 20813831). In many cancers, including glioblastoma and breast cancer, ATF5 is highly overexpressed, contributing to tumor cell persistence and resistance to therapy (Monaco et al., 2007, PMID: 17616666). The 3'UTR contains multiple binding sites for microRNAs (miRNAs), such as miR-520b-3p and miR-141-3p, which naturally downregulate ATF5 expression (Li et al., 2017, PMID: 28415645). Therapeutic strategies targeting this region involve the use of miRNA mimics or antisense oligonucleotides to silence ATF5 expression, thereby triggering selective apoptosis in neoplastic cells while sparing normal tissues (Dluzen et al., 2011, PMID: 21212238). This target is particularly attractive for glioblastoma therapy due to the high dependency of these tumor cells on ATF5 for survival (Angelastro et al., 2006, PMID: 16407537).

Other names

ATF5 3'UTRActivating transcription factor 5 3' untranslated regionATF-5 mRNA 3'UTRATF5 3-prime untranslated region

Binding to the 3'UTR of ATF5 mRNA to facilitate RNA-induced silencing complex (RISC) recruitment or steric hindrance, leading to mRNA degradation or translational repression, which subsequently reduces the levels of the anti-apoptotic ATF5 protein.