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Target intelligence / Profile preview
Activation-induced cytidine deaminase (AID) (AID)
- Target
- AID
- Molecular classification
- Enzyme, Cytidine deaminase, APOBEC family, DNA-editing deaminase
01
Overview
- Other names
- AICDAAIDARP2CDA2HEL-S-284HIGM2Single-stranded DNA cytosine deaminase
02
Mechanism of action
Inhibition of cytidine deaminase activity to prevent DNA deamination and subsequent mutagenic processes; modulation of protein stability via proteasome inhibition; and indirect suppression through B-cell receptor signaling blockade [2, 10, 15].
03
Biological functions
Somatic hypermutationClass-switch recombinationGene conversionDNA deaminationAntibody diversificationActive DNA demethylation
04
Disease associations
Hyper-IgM syndrome type 2B-cell lymphomaChronic lymphocytic leukemiaSystemic lupus erythematosusRheumatoid arthritisChronic myeloid leukemia blast crisis
05
Safety considerations
Secondary immunodeficiencyHyper-IgM syndrome-like phenotype}
06
Interacting drugs
7-aminopyrazolo[1,5-a]pyrimidine derivatives
4 more in the full profile.
07
Biomarkers
AID mRNA expressionAID protein levelsSomatic hypermutation (SHM) frequencySerum IgM levelsSerum IgG levelsmiR-155 expression
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