Gosset Activin A Receptor Type IB Overview
ACVR1B encodes the activin A receptor type IB, a transmembrane serine/threonine kinase that is part of the transforming growth factor-beta (TGF-β) superfamily. It functions as a key signal transducer for activins and related ligands. Upon ligand binding, ACVR2A or ACVR2B first bind the ligand, recruiting and phosphorylating ACVR1B, which then phosphorylates SMAD2/SMAD3 proteins to regulate gene transcription. ACVR1B plays roles in neuronal differentiation, hair follicle development, FSH production, wound healing, immunosuppression and carcinogenesis. Alterations or dysregulation of ACVR1B are implicated in various physiological processes including immune function modulation and carcinogenesis.
Mechanism of Action
Kinase inhibition; modulation of SMAD signaling pathway
Biological Functions
Disease Associations
Safety Considerations
- Potential for off-target effects due to involvement in multiple signaling pathways
- Potential for developmental toxicity