Activin Type II Receptor (ActRII)

Activin Type II Receptor Overview

Activin type II receptors (ActRIIA and ActRIIB) are transmembrane serine/threonine kinases belonging to the TGF-β receptor family. They play a crucial role in signal transduction for TGF-β ligands like activins, myostatin, and GDF11, influencing cell growth, differentiation, apoptosis, muscle mass regulation, and other processes. Upon ligand binding, they form heterotetrameric complexes with type I receptors, leading to Smad protein phosphorylation and gene expression modulation. Dysregulation is associated with diseases like myopathy and leukemia, making them therapeutic targets for muscle-wasting conditions and certain cancers.

Mechanism of Action

Ligand binding induces heterotetramer formation with type I receptors, followed by phosphorylation of Smad proteins and subsequent gene expression changes.

Biological Functions

Safety Considerations

Interacting Drugs