Acyl-CoA:amino acid N-acyltransferase pseudogene (ACNATP)

ACNATP (acyl-CoA:amino acid N-acyltransferase, pseudogene) is annotated as a human pseudogene (GeneCards, NCBI Gene ID: 347275, Ensembl: ENSG00000227411) and does not encode a functional acyltransferase enzyme[1][5]. In other mammals, related genes such as BAAT and BAATP1 (bile acid-CoA:amino acid N-acyltransferase) play active roles in catalyzing the conjugation of bile acids to amino acids (glycine or taurine), a critical step in bile acid metabolism[2][4]. However, ACNATP is a non-functional remnant of such ancestral conjugating enzymes in humans, following the loss of an intact gene during evolution[2]. As it does not encode a protein or have documented functional activity in humans, it is not considered a therapeutic target, receptor, enzyme, or transporter. Notes and clarification: - is_target is false: ACNATP does not produce a functional protein and is not used as a drug target. - is_incorrect is true: While the gene exists, referring to it as a receptor, enzyme, or therapeutic target in humans is misleading; it is a pseudogene, not a functional target. - The terms BAATP1 and other similar names may refer to functional orthologs in other species, but not in humans[2][4]. - No drugs, biomarkers, safety concerns, or disease roles are associated with ACNATP, since it is a non-expressed pseudogene in humans[5][1][2]. Summary: ACNATP is a human pseudogene with no known functional protein product, no therapeutic relevance, and should not be regarded as a receptor, enzyme, or drug target[1][2][5].

Other names

acid-CoA: amino acid N-acyltransferase, pseudogeneBAATP1acyl-coenzyme A amino acid N-acyltransferase pseudogenebile acid-CoA:amino acid N-acyltransferase pseudogene 1ACNATP