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Target intelligence / Profile preview
Acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1)
- Target
- ACAT1
- Molecular classification
- Enzyme, Membrane-bound O-acyltransferase (MBOAT) family
01
Overview
Acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1) is an integral membrane enzyme that catalyzes the formation of cholesteryl esters from cholesterol and long-chain fatty acyl-CoA. It is involved in lipid metabolism, specifically cholesterol storage and transport. ACAT1 is a member of the MBOAT family and is expressed ubiquitously. It plays a role in both ketone body synthesis and breakdown. Mutations in ACAT1 can cause beta-ketothiolase deficiency. It is a therapeutic target for atherosclerosis and Alzheimer's disease.
- Other names
- Acetyl-CoA acetyltransferase 1Mitochondrial acetoacetyl-CoA thiolaseAcetyl-CoA acetyltransferase
02
Mechanism of action
Inhibition of cholesterol esterification
03
Biological functions
Cholesterol esterificationCholesterol storageCholesterol transportKetone body metabolismKetogenesisKetolysisFat breakdown
04
Disease associations
Beta-ketothiolase deficiencyAtherosclerosisAlzheimer’s disease
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