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Target intelligence / Profile preview
Acyl-coenzyme A:cholesterol O-acyltransferase 2 (ACAT2)
- Target
- ACAT2
- Molecular classification
- Enzyme, Acyltransferase, Membrane-bound enzyme
01
Overview
Acyl-coenzyme A cholesterol O-acyltransferase 2 (ACAT2) is an enzyme that catalyzes the formation of cholesteryl esters from cholesterol and long-chain fatty acyl-CoA. It is localized primarily to the endoplasmic reticulum in hepatocytes and enterocytes, and plays a key role in cholesterol homeostasis and lipoprotein assembly. ACAT2 influences plasma lipid profiles and susceptibility to atherosclerosis, making it a potential drug target for treating hypercholesterolemia and preventing cardiovascular disease.
02
Mechanism of action
Inhibition of cholesterol esterification
03
Biological functions
Cholesterol esterificationLipoprotein assemblyCholesterol homeostasisDietary lipid absorption
04
Disease associations
AtherosclerosisHypercholesterolemiaCardiovascular disease
05
Safety considerations
Side effects associated with ACAT inhibitorsLimited efficacy of ACAT inhibitors in clinical trials
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