Acyl-coenzyme A synthetase ACSM6, mitochondrial (ACSM6)

Acyl-coenzyme A synthetase ACSM6, mitochondrial (ACSM6), is an enzyme localized in the mitochondria that catalyzes the ATP-dependent conversion of medium-chain fatty acids (typically C4–C12) into their respective acyl-CoA thioesters[1][2][4][5]. This activation reaction is critical for fatty acid metabolism, serving as the entry step for mitochondrial β-oxidation (energy production) and lipid biosynthetic pathways. The enzyme is predicted to have fatty acid ligase and fatty-acyl-CoA synthase activities. ACSM6 is a member of the acyl-CoA synthetase family, is primarily expressed in various tissues, and may influence metabolic homeostasis, as changes in its activity have been correlated with altered mitochondrial respiration, especially in aging tissues[1][2]. Although dysfunction of ACSM6 or related enzymes may contribute to metabolic disorders, there is currently no evidence of approved drugs or biomarkers specifically targeting ACSM6[2][4][5].

Other names

C10orf129bA310E22.3Acyl-CoA synthetase medium-chain family member 6Acyl-coenzyme A synthetase ACSM6, mitochondrialAMP-binding enzyme

Catalyzes ATP-dependent conversion of medium-chain fatty acids into acyl-CoA thioesters, facilitating their channeling into mitochondrial β-oxidation and lipid biosynthesis[1][2].