adaptor-related protein complex 1, sigma 2 subunit pseudogene

This entry represents a **pseudogene** of the *adaptor-related protein complex 1, sigma 2 subunit* (AP1S2). Pseudogenes are genomic DNA sequences similar to normal genes but are nonfunctional; they do not code for functional proteins. The functional protein, encoded by AP1S2, is a component of the clathrin-associated adaptor protein complex 1, which is involved in vesicle formation at the Golgi complex and plays a role in protein sorting[2][3][11]. However, the **pseudogene itself does not have a known biological or disease-related function** and is not considered a therapeutic target. Key clarification: Do not confuse this pseudogene (ENSG00000280852) with the protein-coding *AP1S2* gene (ENSG00000182287, AP-1 complex subunit sigma-2); the latter is implicated in diseases such as Pettigrew syndrome, but the pseudogene is not functionally relevant[3][4][7].

Other names

adaptor-related protein complex 1 sigma 2 subunit pseudogeneLOC643454