Adenine nucleotide translocator 2 (SLC25A5) mRNA (ANT2 mRNA)

Adenine nucleotide translocator 2 (ANT2), encoded by the SLC25A5 gene, is a mitochondrial carrier protein that facilitates the exchange of ADP and ATP across the inner mitochondrial membrane (UniProt P05141). Unlike other ANT isoforms that are expressed in differentiated tissues, ANT2 is predominantly expressed in proliferating cells and is frequently overexpressed in various malignancies, including breast and liver cancers, to support high metabolic demands and suppress apoptosis (PubMed: 17510401, 22430214). Targeting ANT2 mRNA via RNA interference (RNAi) or antisense oligonucleotides (ASOs) aims to downregulate protein expression, thereby inducing mitochondrial dysfunction, increasing oxidative stress, and triggering programmed cell death (PubMed: 12855581). This strategy is being investigated as a means to inhibit tumor growth and overcome drug resistance in oncology, particularly in cancers that exhibit a glycolytic phenotype (PubMed: 20606248). By silencing the mRNA, researchers can effectively bypass the challenges of directly inhibiting the ANT2 protein, which lacks highly selective small-molecule inhibitors.

Other names

SLC25A5 mRNAAdenine nucleotide translocator 2 mRNAADP/ATP translocase 2 mRNASolute carrier family 25 member 5 mRNAT2 mRNA

RNA interference (RNAi) or antisense-mediated degradation of mRNA leading to reduced protein expression of Adenine nucleotide translocator 2 (PubMed: 17510401).