Gosset Molecular Classification
Tumor-associated antigen, Protein
Other Names
Tumor-associated antigen (TAA) in adenocarcinoma, MAb YH206 antigen
Disease Roles
Adenocarcinoma-associated antigen Overview
Adenocarcinoma-associated antigens are a subset of tumor-associated antigens (TAAs) predominantly expressed in adenocarcinomas. These antigens can be found at elevated levels on tumor cells and may also be present at lower levels in some normal tissues. Their abnormal expression or overexpression is often linked to the malignant transformation process and can trigger an immune response, including the production of autoantibodies in cancer patients. They serve as markers for malignancy and are explored as targets for immunotherapies.
Mechanism of Action
Monoclonal antibodies target and bind to the antigen; vaccines stimulate an immune response against the antigen; adoptive T cell therapies use T cells engineered to target the antigen.
Biological Functions
Malignancy marker
Immunological reporter
Immune response elicitation
Disease Associations
Cancer
Safety Considerations
- Potential for off-target effects in normal tissues expressing low levels of the antigen
- Immunogenicity of therapeutic antibodies
Associated Biomarkers
| Biomarker |
|---|
| Autoantibodies against adenocarcinoma-associated antigens |
| Circulating adenocarcinoma-associated antigens in serum |