Molecular Classification
Enzyme
Other Names
ATP citrate lyase
Disease Roles
CancerCardiovascular diseasePulmonary hypertension

Adenosine triphosphate-citrate lyase Overview

Adenosine triphosphate-citrate lyase (ACLY) is a cytosolic enzyme that catalyzes the conversion of citrate and coenzyme A (CoA) into acetyl-CoA and oxaloacetate, using energy from ATP hydrolysis. It plays a central role in cellular metabolism, providing acetyl-CoA for fatty acid synthesis, cholesterol synthesis, and histone acetylation. ACLY is a therapeutic target in cancer, cardiovascular disease, and vascular remodeling.

Mechanism of Action

Inhibition of ACLY reduces acetyl-CoA production, impacting lipid synthesis, histone acetylation, and tumor cell proliferation.

Biological Functions

Fatty acid synthesis
Cholesterol biosynthesis
Histone acetylation
Metabolic signaling

Disease Associations

Cancer
Cardiovascular disease
Pulmonary hypertension
Hypercholesterolemia

Safety Considerations

  • ETC-1002 may offer improved tolerability compared to statins for patients intolerant to statins, but further safety monitoring is needed.

Interacting Drugs

ETC-1002