Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Adenosine triphosphate-citrate lyase (ACLY)
- Target
- ACLY
- Molecular classification
- Enzyme
01
Overview
Adenosine triphosphate-citrate lyase (ACLY) is a cytosolic enzyme that catalyzes the conversion of citrate and coenzyme A (CoA) into acetyl-CoA and oxaloacetate, using energy from ATP hydrolysis. It plays a central role in cellular metabolism, providing acetyl-CoA for fatty acid synthesis, cholesterol synthesis, and histone acetylation. ACLY is a therapeutic target in cancer, cardiovascular disease, and vascular remodeling.
- Other names
- ATP citrate lyase
02
Mechanism of action
Inhibition of ACLY reduces acetyl-CoA production, impacting lipid synthesis, histone acetylation, and tumor cell proliferation.
03
Biological functions
Fatty acid synthesisCholesterol biosynthesisHistone acetylationMetabolic signaling
04
Disease associations
CancerCardiovascular diseasePulmonary hypertensionHypercholesterolemia
05
Safety considerations
ETC-1002 may offer improved tolerability compared to statins for patients intolerant to statins, but further safety monitoring is needed.
06
Interacting drugs
ETC-1002
Beyond the preview
Go deeper on Adenosine triphosphate-citrate lyase (ACLY).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Adenosine triphosphate-citrate lyase (ACLY).