Adenovirus type 5 capsid protein (null)

Adenovirus type 5 capsid protein Overview

Adenovirus type 5 capsid proteins are structural proteins forming the icosahedral protein shell (capsid) of the human adenovirus serotype 5 (HAdV-C5)[3][5]. The major capsid proteins include hexon (principal coat protein), penton (at the vertices), and fiber (projecting from pentons), while minor proteins such as IIIa, VI, VIII, and IX provide structural support and connect the capsid to the internal core[3][5]. Internal (core) proteins (e.g., V, VII, μ) interact with the viral DNA and help organize and package the genome inside the capsid[1][3]. The capsid serves to protect the viral DNA, facilitate host cell entry, and is essential for the infectivity and stability of the virus particle[2][3][5]. Adenovirus type 5 and its capsid proteins have significant relevance as vectors for gene therapy and vaccine delivery due to the virus’s well-characterized biology, although the capsid itself is not a classical drug target but a viral structural element[2][3]. The term "Adenovirus type 5 capsid proteins" is not a single molecular entity but refers collectively to a set of distinct structural proteins, each with unique functions and characteristics[3][5]. For this reason, it is not accurately described as a single therapeutic "target" and is too broad for standard target modeling purposes[3][5].

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Safety Considerations