Adhesion G protein-coupled receptor F2, pseudogene (ADGRF2P)

Adhesion G protein-coupled receptor F2, pseudogene (ADGRF2P) is a **pseudogene** form of a receptor that would, in other species, encode for the protein Adhesion G protein-coupled receptor F2—a member of the adhesion class of G protein-coupled receptors. In humans, ADGRF2P is classified as a **pseudogene** and is considered non-functional, with no evidence of a translated, active protein product. The predicted product is an orphan receptor (no known ligands), and there is no evidence of physiological function or pharmacological interventions related to the human pseudogene. Nomenclature confusion sometimes occurs with the protein-coding receptor in mouse/rats, where ADGRF2 is functional. In humans, this gene is *not* a valid therapeutic target. **Note:** This entry is often misinterpreted as an active receptor. The correct annotation for the human gene is *pseudogene*; G protein-coupled receptor activity is predicted from homology but is non-functional in the human genome. Mouse and rat orthologs are functional and are keyed as ADGRF2 (without a "P"), but this is not true for the human ortholog. **Summary of issues:** ADGRF2P in humans is a pseudogene and not a functional receptor or drug target. Therefore, it is **not considered a druggable or therapeutic target**. If a functional GPCR is of interest, the non-pseudogene form (in other species, not in human) would be annotated as "Adhesion G protein-coupled receptor F2 (ADGRF2)".

Other names

ADGRF2GPR111PGR20hGPCR35G protein-coupled receptor 111G protein-coupled receptor PGR20Putative adhesion G protein-coupled receptor F2PAdhesion G-protein coupled receptor F2