Adhesion regulating molecule 1 (ADRM1) (ADRM1)

Adhesion regulating molecule 1 (ADRM1), also known as Rpn13, is an integral subunit of the 19S regulatory particle of the 26S proteasome [1]. It serves as a crucial ubiquitin receptor that recognizes and binds polyubiquitinated proteins, facilitating their entry into the proteasome for degradation [2]. ADRM1 is frequently overexpressed in various malignancies, including multiple myeloma and ovarian cancer, where it promotes cell survival and proliferation [3]. Because of its pivotal role in the ubiquitin-proteasome system, ADRM1 has emerged as a promising therapeutic target for cancer treatment [4]. Small molecule inhibitors, such as RA190, target the N-terminal pleckstrin homology domain of ADRM1, effectively blocking its ability to bind ubiquitin and triggering apoptosis in cancer cells [2, 5]. This approach provides a distinct mechanism compared to traditional 20S proteasome inhibitors, potentially overcoming resistance in clinical settings [5].

Other names

Rpn13ARM-1GP110Proteasome regulatory particle non-ATPase subunit 13

Inhibition of the 19S regulatory particle by binding to the Rpn13 subunit, preventing the degradation of polyubiquitinated proteins and inducing proteotoxic stress and apoptosis.