Gosset Molecular Classification
Enzyme
Disease Roles
Adipose Tissue Lipid Synthesis Enzymes Overview
Adipose tissue lipid synthesis enzymes are a group of proteins that catalyze the formation and storage of lipids (primarily triglycerides) in adipocytes. Key enzymes include Acyl-CoA:Diacylglycerol Acyltransferase (DGAT), Fatty Acid Synthase (FAS), and Lipoprotein Lipase (LPL). These enzymes play central roles in energy homeostasis, metabolic health, and the regulation of whole-body lipid metabolism. Alterations or mutations affecting these enzymes have been linked to obesity, insulin resistance and represent potential targets for metabolic therapies.
Mechanism of Action
Varied, depending on the specific enzyme targeted. Examples include inhibition of DGAT, FAS, or modulation of LPL activity.
Biological Functions
Triglyceride biosynthesis
Fatty acid biosynthesis
Lipid storage
Energy homeostasis
Regulation of lipid metabolism
Disease Associations
Obesity
Metabolic syndrome
Insulin resistance
Safety Considerations
- Potential for off-target effects on lipid metabolism in other tissues
- Unintended consequences on energy homeostasis
- Development of drug resistance