Adoptive Transfer of Donor T-cells (ATDC)

Adoptive transfer of donor T-cells is a form of immunotherapy in which T lymphocytes are isolated from a donor, expanded or modified ex vivo, and then infused into a recipient to restore or enhance immune function. This approach leverages the specificity and potency of the adaptive immune response by providing patients with functional effector/memory populations that may otherwise be absent or dysfunctional due to disease or treatment effects. It is used to treat diseases such as cancer, viral infections, and immune deficiencies.

Other names

Donor T-cell ImmunotherapyT-cell adoptive immunotherapyAdoptive cell therapy (ACT) with T-cells

Donor T-cells recognize and eliminate target cells expressing specific antigens (e.g., tumor-associated antigens or viral antigens). CD4+ T cells provide help for antibody production and CD8+ T cells mediate direct cytotoxicity.