ADP-ribosyltransferase 2, pseudogene (ART2P)

ADP-ribosyltransferase 2, pseudogene (ART2P) is designated as a pseudogene in the human genome and is not a functional protein-coding gene[2][5][6]. In rodents, the homologous gene encodes an ecto-enzyme that participates in NAD^+-dependent ADP-ribosylation of cell surface proteins, but in humans and other primates, only the nonfunctional pseudogene remains[1][5]. As such, ART2P does not encode an active target for therapeutic intervention, has no known biological functions or disease associations in humans, and is not a receptor, enzyme, transporter, or other drug-targetable entity[1][5][2]. Summary of key facts: - ART2P is specifically annotated as a pseudogene in humans. - Its aliases include ART1P, ARTC2AP, and RT6[2]. - The functional product (ARTC2.2) exists in rodents, where it modulates immune signaling, but this function is absent in humans due to inactivation of the gene[1]. - ART2P is not considered a drug target or associated with human diseases, drugs, or safety issues. This target is thus considered incorrect as a therapeutic target in clinical or translational research contexts for humans, given its lack of protein-coding capacity and biological/clinical relevance[2][5][6].

Other names

ART1PARTC2APRT6