Molecular Classification
G protein-coupled receptor, GPCR
Other Names
Adrenergic beta receptor, Beta-adrenergic receptor, β-adrenergic receptor, Beta adrenoceptor, β-adrenoceptor
Disease Roles
HypertensionArrhythmiasAngina pectoris

Adrenergic Beta-Receptor Overview

Adrenergic beta-receptors are GPCRs divided into three main subtypes (β1, β2, β3) that mediate critical cardiovascular, metabolic, and respiratory functions by transducing catecholamine signals into cellular responses through cAMP-dependent pathways. Their pharmacological modulation is central to treatment strategies across several major diseases.

Mechanism of Action

Agonists stimulate adenylyl cyclase via G_s protein activation, increasing cAMP levels and activating PKA. Antagonists block the receptor, preventing catecholamine binding and downstream signaling.

Biological Functions

Signal transduction
Regulation of cardiac function
Regulation of smooth muscle tone
Regulation of metabolism
Bronchodilation
Lipolysis
Renin release

Disease Associations

Hypertension
Arrhythmias
Angina pectoris
Heart failure
Asthma
COPD
Overactive bladder

Safety Considerations

  • Bradycardia
  • Hypotension
  • Bronchospasm
  • Heart block

Interacting Drugs

Beta-blockers
Adrenaline (epinephrine)
Noradrenaline (norepinephrine)