Gosset Molecular Classification
Neurotransmission pathway, Signaling pathway
Disease Roles
Adrenergic Neurotransmission Overview
Adrenergic neurotransmission refers to the process by which nerve cells communicate using catecholamine neurotransmitters—primarily norepinephrine (noradrenaline), epinephrine (adrenaline), and, to a lesser extent, dopamine. These neurotransmitters are released from adrenergic neurons and bind to adrenergic receptors on target cells, mediating various physiological processes, including cardiovascular, respiratory, metabolic, and central nervous system functions. Dysfunctional adrenergic signaling is implicated in diseases ranging from depression/anxiety disorders to heart failure.
Mechanism of Action
Modulation of adrenergic receptor activity via agonists or antagonists, influencing downstream signaling pathways.
Biological Functions
Regulation of cardiovascular function
Regulation of respiratory function
Regulation of metabolic processes
Modulation of central nervous system activity
Fight-or-flight response
Arousal
Attention modulation
Learning and memory formation
Emotional responses (anxiety, stress adaptation)
Disease Associations
Hypertension
Asthma
Depression
Anxiety disorders
Heart failure
Safety Considerations
- Cardiovascular side effects (e.g., increased heart rate, blood pressure)
- Central nervous system effects (e.g., anxiety, insomnia)
Interacting Drugs
Adrenergic agonists
Adrenergic antagonists