Molecular Classification
G protein-coupled receptor, Receptor
Other Names
Beta-1 adrenergic receptor, ADRB1 receptor, Beta1AR
Disease Roles
HypertensionArrhythmiasHeart failure

Adrenergic Receptor Beta 1 Overview

The beta-1 adrenergic receptor (ADRB1) is a G-protein-coupled receptor that mediates physiological responses to catecholamines, particularly epinephrine and norepinephrine. It is predominantly expressed in cardiac tissue and regulates heart rate, contractility, and conduction velocity. Activation increases cardiac output. It is a major drug target for cardiovascular diseases, especially hypertension, arrhythmias, and heart failure.

Mechanism of Action

Beta-1 adrenergic receptor antagonists (beta-blockers) inhibit the activity of the receptor, reducing heart rate and contractility.

Biological Functions

Signal transduction
Regulation of heart rate
Regulation of cardiac contractility
Regulation of sleep/wake behavior

Disease Associations

Hypertension
Arrhythmias
Heart failure
Cardiovascular disease
CNS disorders

Safety Considerations

  • Bradycardia
  • Hypotension
  • Heart block

Interacting Drugs

Epinephrine
Norepinephrine
Metoprolol