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Target intelligence / Profile preview
Adrenergic Receptor Beta 1 (ADRB1)
- Target
- ADRB1
- Molecular classification
- G protein-coupled receptor, Receptor
01
Overview
The beta-1 adrenergic receptor (ADRB1) is a G-protein-coupled receptor that mediates physiological responses to catecholamines, particularly epinephrine and norepinephrine. It is predominantly expressed in cardiac tissue and regulates heart rate, contractility, and conduction velocity. Activation increases cardiac output. It is a major drug target for cardiovascular diseases, especially hypertension, arrhythmias, and heart failure.
- Other names
- Beta-1 adrenergic receptorADRB1 receptorBeta1AR
02
Mechanism of action
Beta-1 adrenergic receptor antagonists (beta-blockers) inhibit the activity of the receptor, reducing heart rate and contractility.
03
Biological functions
Signal transductionRegulation of heart rateRegulation of cardiac contractilityRegulation of sleep/wake behavior
04
Disease associations
HypertensionArrhythmiasHeart failureCardiovascular diseaseCNS disorders
05
Safety considerations
BradycardiaHypotensionHeart block
06
Interacting drugs
Epinephrine
2 more in the full profile.
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