Advanced glycosylation end product-specific receptor (AGER) mRNA (AGER mRNA)

AGER mRNA encodes the Advanced glycosylation end product-specific receptor (RAGE), a multi-ligand cell surface molecule of the immunoglobulin superfamily (UniProt: Q15109). RAGE functions as a pattern recognition receptor that interacts with diverse ligands, including advanced glycation end products (AGEs), high mobility group box 1 (HMGB1), S100 proteins, and amyloid-beta (PubMed: 28232324). These interactions activate pro-inflammatory signaling pathways, such as NF-κB and MAPK, contributing to chronic inflammation, oxidative stress, and tissue damage (PubMed: 18448634). AGER expression is significantly upregulated in various pathological states, including diabetes-related complications, Alzheimer's disease, cardiovascular disorders, and certain cancers (NCBI Gene: 177). Therapeutic strategies targeting AGER mRNA, such as antisense oligonucleotides (ASOs) and small interfering RNAs (siRNAs), are being explored to silence RAGE expression and mitigate its role in disease progression (PubMed: 22403074). While small molecule inhibitors like Azeliragon target the protein directly, mRNA-based approaches offer a potential method for long-term suppression of the receptor's pro-inflammatory signaling (PubMed: 30554100).

Other names

RAGE mRNAReceptor for advanced glycation endproducts mRNAAGER transcriptAdvanced glycosylation end product-specific receptor mRNA

RNA interference (RNAi) or antisense-mediated degradation of the AGER transcript to prevent translation of the RAGE protein.