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Aggregated Tau Protein (Aggregated Tau)
- Target
- Aggregated Tau
- Molecular classification
- Protein aggregate, Intracellular protein, Microtubule-associated protein (modified)
01
Overview
Aggregated tau protein refers to the abnormal accumulation and clustering of tau proteins into insoluble aggregates within neurons, a pathological hallmark of Alzheimer's disease (AD) and other tauopathies. Hyperphosphorylation and truncation of tau are key drivers of aggregation, leading to disruption of microtubule function, impaired axonal transport, and neuronal degeneration. It is a therapeutic target.
- Other names
- Neurofibrillary TanglesTau aggregatesInsoluble TauHyperphosphorylated TauPHF-TauSF-Tau
02
Mechanism of action
Inhibition of tau aggregation; promotion of aggregate disassembly; prevention of hyperphosphorylation; enhancement of microtubule stability
03
Biological functions
Microtubule disruptionAxonal transport impairmentSynaptic dysfunctionNeuronal degenerationSequestration of soluble Tau
04
Disease associations
Alzheimer's DiseaseTauopathiesFrontotemporal DementiaProgressive Supranuclear PalsyCorticobasal DegenerationChronic Traumatic Encephalopathy
05
Safety considerations
Blood-brain barrier penetrationOff-target effects of kinase inhibitorsPotential for neuroinflammationLack of clinical efficacy in some trials
06
Interacting drugs
Small molecule inhibitors of tau aggregation
4 more in the full profile.
07
Biomarkers
CSF Tau levelsCSF p-Tau levelsPET imaging of tau aggregatesPlasma p-Tau levels
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