Gosset Molecular Classification
Signal Transduction Pathway
Other Names
PI3K-Akt Signaling Pathway, Akt/PKB Pathway, PKB/Akt Signaling
Disease Roles
Akt Pathway Overview
The Akt pathway, also known as the PI3K-Akt signaling pathway or Akt/PKB pathway, is a critical intracellular signal transduction cascade that regulates cell survival, growth, proliferation, metabolism, and angiogenesis in response to extracellular signals such as growth factors. The core components of this pathway are phosphatidylinositol 3-kinase (PI3K) and Akt (also called protein kinase B or PKB).
Mechanism of Action
Inhibition of PI3K, Akt, or downstream targets like mTOR to disrupt signaling.
Biological Functions
Cell survival
Cell growth
Cell proliferation
Metabolism
Angiogenesis
Signal transduction
Disease Associations
Cancer
Type II Diabetes
Safety Considerations
- Off-target effects due to pathway complexity
- Development of resistance
Interacting Drugs
Akt inhibitors
Associated Biomarkers
| Biomarker |
|---|
| Akt phosphorylation status |
| PTEN expression |