Gosset Molecular Classification
Enzyme, Transaminase
Other Names
Alanine aminotransferase, ALAT, Serum glutamic-pyruvic transaminase, SGPT, GPT
Disease Roles
Alanine transaminase Overview
Alanine transaminase (ALT), also known as alanine aminotransferase, is an enzyme that catalyzes the reversible transfer of an amino group from L-alanine to α-ketoglutarate, producing pyruvate and L-glutamate. It is primarily found in the liver and serves as a sensitive biomarker for hepatocellular injury and disease. Elevated ALT levels in the blood indicate liver damage, making it a key component of liver function tests.
Mechanism of Action
Biological Functions
Nitrogen metabolism
Gluconeogenesis
Energy production
Amino acid balance
Amino group transfer
Disease Associations
Hepatitis
Fatty liver disease (MASLD/NAFLD)
Cirrhosis
Drug-induced liver injury
Liver damage
Alcoholic liver disease
Safety Considerations
- Elevated levels indicate potential liver damage
Associated Biomarkers
| Biomarker |
|---|
| ALT levels for liver health |
| AST/ALT ratio for liver disease differentiation |