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Albumin (DNSA-binding site) (None)

Target: None
Molecular classification: Protein, Transport Protein

Overview

The DNSA-binding site is a specific region (region Ib) within Site I on human serum albumin (HSA), located in subdomain IIA. It is characterized by its high affinity for Dansyl-L-asparagine (DNSA). This site plays a crucial role in the transport of various drugs and endogenous substances by albumin. Ligand binding to this region is reversible, leading to potential drug-drug interactions due to competition for binding. Understanding this site is important for predicting pharmacokinetic profiles and potential adverse effects during polypharmacy.

Mechanism of action

Reversible binding of drugs and other ligands, influencing their distribution and availability.

Biological functions

Drug transportLigand bindingRegulation of drug distributionRegulation of drug free concentration

Disease associations

Drug-drug interactionsAltered drug pharmacokinetics

Safety considerations

Drug-drug interactions due to competition for binding sitesAltered drug efficacy or toxicity

Interacting drugs

Dansyl-L-asparagine (DNSA)

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