Aldehyde oxidase 2, pseudogene (AOX2P)

Aldehyde oxidase 2, pseudogene (AOX2P) is an inactivated segment of the aldehyde oxidase gene family located on human chromosome 2q[1]. In humans, only one aldehyde oxidase gene (AOX1) is functional; AOX2P and related AOX3L1 pseudogenes do not encode active enzymes[1]. These pseudogenes arose evolutionarily from a series of gene duplications and subsequent mutations causing loss of function, distinguishing them from catalytically active aldehyde oxidase isoforms found in some mammals such as mice and rats[1]. AOX2P does not produce a functional protein and therefore has no known physiological roles, disease associations, or drug interactions[1]. Its presence reflects the evolutionary history of the aldehyde oxidase gene family rather than current biological activity.

Other names

AOH2AOX2AOX3L1AOX2P