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Alkylating Agent
- Molecular classification
- Chemical entity, Antineoplastic agent, DNA damaging agent
01
Overview
Alkylating agents are cytotoxic compounds that work primarily through covalent modification (“alkylation”) of cellular macromolecules—especially nucleic acids—leading directly or indirectly to inhibition of proliferation and induction of apoptosis. Their broad utility across many cancers is balanced by significant side effects related mainly to non-selective targeting.
02
Mechanism of action
Covalent binding/alkylation of nucleic acids; inhibits replication/transcription
03
Biological functions
DNA alkylationInhibition of DNA replicationInduction of apoptosisCytotoxicity
04
Disease associations
CancerAutoimmune diseases
05
Safety considerations
Bone marrow suppressionGastrointestinal toxicityGonadal toxicity (infertility)Secondary malignanciesMutagenicity
06
Interacting drugs
Cyclophosphamide
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