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Target intelligence / Profile preview
Alpha-(1,3)-fucosyltransferase 4 (FUT4)
- Target
- FUT4
- Molecular classification
- Enzyme, Glycosyltransferase (sub-class: fucosyltransferase)
01
Overview
Alpha-(1,3)-fucosyltransferase 4 (FUT4) is an enzyme that catalyzes the transfer of fucose from GDP-fucose to N-acetylglucosamine within N-acetyllactosamine polysaccharides to produce fucosylated carbohydrates, notably the Lewis x antigen (CD15)[1][4][5]. The Lewis x antigen is important in cell-cell adhesion and has roles in normal myeloid differentiation and in malignancy transformation. FUT4 is a member of the glycosyltransferase family specialising in the alpha(1,3)-fucosylation of glycoproteins and glycolipids. Its dysfunction or overexpression has been linked to tumor progression, immunological changes, and aberrant cell signaling[1][3][5].
- Other names
- Fucosyltransferase 4Alpha(1,3) fucosyltransferase (myeloid-specific)FUT4
02
Mechanism of action
Inhibition of fucosyltransferase catalytic activity (glycosylation inhibition)
03
Biological functions
GlycosylationSynthesis of fucosylated carbohydrate structuresCell adhesionGeneration of Lewis x antigen (CD15)
04
Disease associations
Cancer (especially via altered glycosylation contributing to tumor progression and metastasis)Other (potential roles in immune response due to cell surface antigen modification)
05
Safety considerations
Targeting glycosyltransferases may affect normal glycoprotein processing in multiple tissues, risk of off-target effects and immune reactions; precise concern details not specified in supplied sources
06
Interacting drugs
No drugs directly targeting FUT4 are established in clinical use; investigational agents and glycosylation inhibitors may affect FUT4 indirectly
07
Biomarkers
Lewis x antigen (CD15) as marker of fucosyltransferase activity
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