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Target intelligence / Profile preview
Alpha-1,3-galactosyltransferase (αGT)
- Target
- αGT
- Molecular classification
- Enzyme, Glycosyltransferase, Type II transmembrane protein
01
Overview
Alpha-1,3-galactosyltransferase (αGT) is a glycosyltransferase enzyme responsible for synthesizing the Galα(1–3)Galβ(1–4)GlcNAc epitope (alpha-Gal). It is absent in humans, apes, and Old World monkeys, leading to the production of anti-alpha-Gal antibodies. Its presence in other mammals poses a significant barrier to xenotransplantation. Furthermore, the alpha-Gal epitope is implicated in IgE-mediated allergic reactions following tick bites. Recombinant forms can be used for *in vitro* glycoprotein modification.
- Other names
- Alpha-(1→3)-galactosyltransferaseα₁₋₃GalTN-acetyllactosaminide alpha-(13)-galactosyltransferaseGGTAGALT
02
Mechanism of action
Catalyzes the transfer of a galactose residue from UDP-galactose to terminal N-acetyllactosamine units, forming an α-1,3 linkage.
03
Biological functions
GlycosylationSynthesis of Galα(1–3)Galβ(1–4)GlcNAc epitopeImmune response modulation
04
Disease associations
Xenotransplantation rejectionAlpha-gal syndrome (red meat allergy)Potential role in pathogen defense
05
Safety considerations
Hyperacute rejection in xenotransplantationIgE-mediated allergic reactions (alpha-gal syndrome)
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