Target intelligence / Profile preview

Alpha-1,6-glucosidase

Molecular classification: Enzyme, Glycoside hydrolase

Overview

Alpha-1,6-glucosidase is an enzyme that catalyzes the hydrolysis of α(1→6)-glycosidic bonds in glycogen and related polysaccharides. This activity is crucial for the complete degradation of glycogen during glycogenolysis. In humans, this function is performed by the AGL gene product. Mutations in AGL cause Glycogen Storage Disease Type III (Cori disease).

Mechanism of action

Hydrolyzes α(1→6)-glucose linkages in glycogen limit dextrin branches, releasing free glucose.

Biological functions

GlycogenolysisHydrolysis of glycosidic bondsCarbohydrate metabolism

Disease associations

Glycogen Storage Disease Type III (Cori disease)

Safety considerations

Inhibition of alpha-1,6-glucosidase can lead to accumulation of abnormal glycogen.Dysregulation can result in hypoglycemia or hyperglycemia.

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