Alpha-1D adrenergic receptor (ADRA1D) (ADRA1D)

The Alpha-1D adrenergic receptor (ADRA1D) is a G protein-coupled receptor that plays a pivotal role in the sympathetic nervous system by mediating the actions of norepinephrine and epinephrine (UniProt: P25100). It is widely distributed in the cardiovascular system, particularly in the aorta and coronary arteries, as well as in the bladder and prostate (PubMed: 21892148). Upon activation, ADRA1D couples with Gq/11 proteins to stimulate phospholipase C, resulting in increased intracellular calcium and smooth muscle contraction (IUPHAR: Alpha1D-adrenoceptor). This receptor is a significant therapeutic target for conditions such as hypertension and benign prostatic hyperplasia (BPH), where its antagonism leads to vasodilation and improved urinary flow (StatPearls: NBK539830). Research also suggests its involvement in central nervous system functions and glucose homeostasis, making it a subject of interest for metabolic and neurological studies (PubMed: 25635034). In the context of BPH, ADRA1D is specifically noted for its high expression in the human prostate and bladder neck, contributing to the dynamic component of urinary obstruction. Selective and non-selective antagonists are used clinically to manage these symptoms by reducing muscle tone. Understanding the subtype-specific roles of alpha-1 receptors remains crucial for developing drugs with improved safety profiles and reduced cardiovascular side effects.

Other names

Alpha-1D adrenoceptorAlpha-1A adrenergic receptor (historical) (PubMed: 21892148)ADRA1A (historical)Alpha-1D adrenoreceptor

Competitive antagonism of alpha-1 adrenergic receptors, leading to the relaxation of smooth muscle in the vasculature and lower urinary tract (PubMed: 21892148).