Gosset Molecular Classification
Serine protease inhibitors (serpins)
Other Names
α2-antiplasmin, α2-plasmin inhibitor, Plasmin inhibitor, SERPINF2
Disease Roles
Alpha-2 antiplasmin Overview
Alpha-2 antiplasmin (α2AP), also known as plasmin inhibitor, is a key serine protease inhibitor (serpin) that plays a central role in regulating fibrinolysis by inactivating plasmin, the primary enzyme responsible for breaking down blood clots. It is primarily synthesized by hepatocytes in the liver and released into circulation.
Mechanism of Action
Inhibits plasmin by forming a stable complex, preventing fibrin clot breakdown.
Biological Functions
Inhibition of fibrinolysis
Regulation of hemostasis
Plasmin neutralization
Disease Associations
Bleeding disorders (deficiency)
Thrombosis (elevated levels)
Ischemic stroke (elevated levels)
Safety Considerations
- Deficiency leads to increased risk of bleeding
- Elevated levels associated with increased risk of ischemic stroke