Alpha-ketoglutarate dehydrogenase (α-KGDH)

Alpha-ketoglutarate dehydrogenase Overview

Alpha-ketoglutarate dehydrogenase (α-KGDH) is a mitochondrial enzyme complex that plays a central role in cellular energy metabolism. It catalyzes the irreversible oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA and CO₂, producing NADH in the process. This reaction is a key step in the Krebs cycle, which is essential for ATP production through oxidative phosphorylation. Impaired function or deficiency of α-KGDH leads to disruption of energy metabolism, and dysfunction has been implicated in neurodegenerative diseases due to its sensitivity to ROS and central role in neuronal metabolism. It also regulates post-translational modification via lysine succinylation.

Mechanism of Action

Biological Functions

Safety Considerations