Alpha-Klotho messenger RNA (KL mRNA) (KL mRNA)

Alpha-Klotho messenger RNA (KL mRNA) is the transcript of the KL gene, which encodes the alpha-Klotho protein, a critical regulator of aging and mineral metabolism [UniProt Q9UEF7]. Primarily expressed in the renal distal convoluted tubules and the choroid plexus of the brain, Klotho acts as an essential co-receptor for fibroblast growth factor 23 (FGF23) to maintain phosphate and vitamin D homeostasis [Nature Reviews Nephrology, 2019]. Beyond its role in mineral metabolism, Klotho functions as a circulating hormone with potent anti-oxidative, anti-inflammatory, and anti-senescence properties [JASN, 2011]. A decline in Klotho expression is a hallmark of chronic kidney disease (CKD) and is associated with accelerated aging, cardiovascular complications, and cognitive decline [Nature Reviews Nephrology, 2009]. Therapeutic approaches utilizing Klotho-encoding mRNA aim to restore endogenous protein levels through transient expression, offering a potential strategy to mitigate the progression of age-related and metabolic diseases [Molecular Therapy, 2020]. This modality is particularly attractive because it avoids the genomic integration risks associated with DNA-based gene therapy while providing the necessary protein for systemic or local action. Current research focuses on optimizing lipid nanoparticle (LNP) delivery systems to target the kidneys or liver for sustained protein secretion.

Other names

Klotho-encoding messenger RNAKL mRNAalpha-Klotho mRNAKlotho transcriptKLS mRNA

Translation of exogenous mRNA into functional alpha-Klotho protein to restore physiological signaling and cytoprotective functions.