Alpha platelet-derived growth factor receptor (PDGFRA)

Molecular Classification

Receptor tyrosine kinase

Other Names

CD140a

Disease Roles

Gastrointestinal stromal tumors (GISTs)Clonal hypereosinophilia malignanciesCancer

Alpha platelet-derived growth factor receptor Overview

The alpha platelet-derived growth factor receptor (PDGFRA), also known as CD140a, is a cell surface receptor tyrosine kinase that binds PDGF isoforms, activating signaling pathways regulating cell growth, differentiation, and development. It plays critical roles in embryonic development and tissue maintenance. Mutations or aberrant activity are linked to several neoplasms, including GISTs and clonal hypereosinophilia.

Mechanism of Action

Tyrosine kinase inhibition

Biological Functions

Cell proliferation

Cell differentiation

Cell migration

Cell survival

Wound healing

Regulation of cell migration

Chemotaxis

Platelet activation

Disease Associations

Gastrointestinal stromal tumors (GISTs)

Clonal hypereosinophilia malignancies

Cancer

Developmental disorders

Safety Considerations

No safety concerns listed