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Target intelligence / Profile preview
Alpha-synuclein aggregate (N/A)
- Target
- N/A
- Molecular classification
- Protein aggregate
01
Overview
Alpha-synuclein aggregates are abnormal accumulations of the alpha-synuclein protein, primarily found in presynaptic terminals. These aggregates are central to the pathology of several neurodegenerative diseases, most notably Parkinson’s disease and other synucleinopathies. In its aggregated form, alpha-synuclein misfolds into β-sheet-rich fibrils that accumulate as Lewy bodies and Lewy neurites within neurons. These aggregates are considered a therapeutic target for disease modification.
- Other names
- Lewy bodiesLewy neuritesAlpha-synuclein fibrilsAggregated alpha-synucleinSNCA aggregates
02
Biological functions
NeurotoxicityMitochondrial dysfunctionOxidative stressApoptosisSynaptic dysfunction
03
Disease associations
Parkinson's DiseaseDementia with Lewy BodiesMultiple System AtrophySynucleinopathiesNeurodegenerative disease
04
Safety considerations
Off-target effectsImmune responseBlood-brain barrier penetrationNon-selective aggregate targetingUnintended consequences of disrupting protein homeostasis
05
Biomarkers
Alpha-synuclein levels in cerebrospinal fluidAlpha-synuclein levels in bloodImaging of alpha-synuclein aggregates
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