Alpha3beta4 nicotinic acetylcholine receptor (α3β4 nAChR)

Molecular Classification

Ligand-gated ion channel, Nicotinic acetylcholine receptor

Other Names

Ganglion-type nicotinic receptor

Disease Roles

AddictionLung cancer

Alpha3beta4 nicotinic acetylcholine receptor Overview

The alpha3beta4 nicotinic acetylcholine receptor (α3β4 nAChR) is a subtype of neuronal nicotinic acetylcholine receptors, playing a critical role in fast synaptic transmission within the autonomic ganglia and adrenal medulla. It is also present in specific brain regions like the medial habenula (MHb) and interpeduncular nucleus (IPN), implicated in reward circuits and addiction behaviors. Activation leads to rapid depolarization due to cation influx. It has emerged as a promising target for anti-addiction therapies.

Mechanism of Action

Agonist or antagonist binding modulates ion channel opening and cation flux.

Biological Functions

Fast synaptic transmission

Neuronal excitability modulation

Autonomic function

Reward processing

Sensory modulation

Disease Associations

Addiction

Lung cancer

Safety Considerations

Potential for off-target effects on other nicotinic receptor subtypes

Interacting Drugs

Acetylcholine

Nicotine

Carbachol

Cytisine

Epibatidine

Lobeline

DHβE

SR 16584

Mecamylamine

Hexamethonium

Dextromethorphan

Dextrorphan

Dextropropoxyphene

Imipramine

Methadone

Levacetylmethadol

Bupropion

Reboxetine

Ibogaine

Voacangine

AT-1001

Choline

Tubocurarine

Associated Biomarkers

Biomarker
CHRNA5/A3/B4 gene cluster variations