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Target intelligence / Profile preview
Alveolar Surface Tension (N/A)
- Target
- N/A
- Molecular classification
- Biophysical Property
01
Overview
Alveolar surface tension is the force exerted by water molecules at the air-liquid interface lining the alveoli in the lungs. It is a critical biophysical property that affects lung mechanics and alveolar stability. While necessary for normal lung function, excessive surface tension can lead to alveolar collapse. Pulmonary surfactant, produced by type II pneumocytes, reduces alveolar surface tension, preventing atelectasis and facilitating efficient respiration.
- Other names
- Lung Surface TensionPulmonary Surface Tension
02
Mechanism of action
Exogenous surfactant reduces alveolar surface tension, preventing collapse and improving gas exchange.
03
Biological functions
Lung mechanicsAlveolar stabilityGas exchangeBreathing
04
Disease associations
Respiratory distress syndromeAtelectasisAcute respiratory distress syndrome (ARDS)
05
Safety considerations
Barotrauma (from mechanical ventilation)Oxygen toxicityInfection
06
Interacting drugs
Exogenous Surfactant (e.g., Beractant, Poractant alfa, Calfactant)
07
Biomarkers
Surfactant protein levels (e.g., SP-B)Oxygen saturationA-a gradientLung compliance
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