Gosset Molecular Classification
Enzyme, Transferase, Amidotransferase
Other Names
GPAT, Glutamine phosphoribosylpyrophosphate amidotransferase, Phosphoribosylpyrophosphate amidotransferase, PurF gene product
Disease Roles
Amidophosphoribosyltransferase Overview
Amidophosphoribosyltransferase (ATase), also known as glutamine phosphoribosylpyrophosphate amidotransferase (GPAT), is a key enzyme in the de novo purine biosynthesis pathway. It catalyzes the conversion of 5-phosphoribosyl-1-pyrophosphate (PRPP) and glutamine into 5-phosphoribosyl-1-amine (PRA). This reaction represents the first committed step in purine nucleotide synthesis and is essential for cell proliferation and DNA/RNA production. It is a potential target for anti-cancer and anti-infective therapies.
Mechanism of Action
Inhibition of de novo purine synthesis
Biological Functions
Catalysis
Purine nucleotide synthesis
De novo IMP biosynthetic process
Glutamine metabolic process
Purine metabolic process
Pyrimidine metabolic process
Nucleobase metabolic process
Nucleotide metabolic processes
Disease Associations
Cancer
Infection
Safety Considerations
- Potential for broad toxicity due to essential role in cell proliferation