Target intelligence / Profile preview

Amine Oxidase [Flavin-Containing] A (MAO-A)

Target: MAO-A
Molecular classification: Enzyme, Oxidoreductase, Flavoenzyme

Overview

Amine oxidase [flavin-containing] A (MAO-A) is a mitochondrial outer membrane-bound flavoenzyme that catalyzes the oxidative deamination of primary and some secondary amines, including key neurotransmitters such as serotonin, norepinephrine, and dopamine. It plays a critical role in regulating neuroactive and vasoactive amines in both the central nervous system and peripheral tissues. MAO-A is a target for antidepressant and anti-anxiety medications.

Other names: Monoamine Oxidase AMAOA

Mechanism of action

Inhibition of monoamine oxidase A, preventing the breakdown of monoamine neurotransmitters.

Biological functions

Neurotransmitter metabolismRegulation of monoamine levelsOxidative deamination

Disease associations

DepressionAnxietyPsychiatric disorders

Safety considerations

Hypertensive crisis (with tyramine-containing foods)Serotonin syndrome (with other serotonergic drugs)

Interacting drugs

Selective MAO-A inhibitors (e.g., moclobemide, clorgyline)

Biomarkers

MAOA gene polymorphisms (e.g., VNTR)MAO-A activity levels in platelets

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